Buffalo Bills wide receiver DJ Moore (shoulder) faces an appealing matchup against the Las Vegas Raiders in Week 6, but his availability remains uncertain after missing Monday's overtime win over the Rams. Moore is questionable after sitting out practice Wednesday and Thursday before returning in a limited capacity Friday. The 29-year-old initially injured his shoulder against Detroit in Week 2 and aggravated it against New England in Week 4. His season totals of 12 receptions for 178 yards and one touchdown are heavily influenced by a five-catch, 100-yard performance against Houston in the opener. Across his other three appearances, Moore has managed just seven receptions for 78 yards. Las Vegas presents an opportunity for a rebound after allowing Drake Maye to throw for 374 yards and four touchdowns last week. Still, Moore's health and uncertain workload make him a risky WR3/flex option even if he plays. Fantasy managers should have an alternative available with Buffalo not kicking off until 4:25 p.m. ET.

Los Angeles Rams tight end Tyler Higbee has caught at least five passes for 60 yards in three consecutive games, putting him in a favorable position for Sunday's Week 6 matchup against the Arizona Cardinals. Since Terrance Ferguson (ankle) went down, Higbee has caught 18 of 23 targets for 212 yards and a touchdown, including five receptions for a season-high 83 yards against Buffalo in Week 5. He played 67% of the offensive snaps in that contest, while fellow tight end Colby Parkinson managed just two targets despite playing a similar number of snaps. Arizona has been particularly vulnerable against tight ends, surrendering 258 receiving yards and four touchdowns to the position over its last three games. Higbee has become a reliable receiving option for Matthew Stafford, and Ferguson's continued absence should help preserve his opportunities. He is a worthwhile Week 6 streaming option, especially in PPR leagues, with the potential to deliver low-end TE1 production.

Los Angeles Rams running back Kyren Williams has caught 22 passes over his last three games, adding another dimension to his fantasy production heading into Sunday's Week 6 matchup against the Arizona Cardinals. Williams rushed 16 times for 49 yards and a touchdown in Monday's overtime loss to Buffalo, while catching six of eight targets for another 27 yards. He played 73% of the offensive snaps, maintaining his lead role despite Blake Corum scoring on one of his five carries and adding three receptions for 53 yards. Arizona offers an appealing opportunity after allowing Jahmyr Gibbs to rush for 151 yards and two touchdowns in last week's 45-21 loss to Detroit. Williams has already scored five total touchdowns through five games, and his increased receiving involvement provides another avenue for production when rushing yards are harder to come by. He remains a high-end RB1 and should be locked into starting lineups across all fantasy formats.

Los Angeles Rams wide receiver Davante Adams draws a favorable Week 6 matchup against the Arizona Cardinals after catching five of seven targets for 51 yards and two touchdowns in Monday's overtime loss to Buffalo. The veteran has now recorded 27 receptions for 441 yards and four touchdowns through five games, drawing at least seven targets in each of his past four appearances. His yardage has fluctuated considerably, including a four-catch, 32-yard outing against Philadelphia in Week 4, but the opportunities have remained steady. Puka Nacua commanded a remarkable 24 targets against Buffalo, leaving Adams with a smaller share of Matthew Stafford's passing volume than usual. Still, Arizona presents an appealing matchup after allowing three passing touchdowns in last week's 45-21 loss to Detroit, including two to Jameson Williams. Adams remains a strong weekly starter with WR1 potential, particularly against a Cardinals defense that has struggled to keep opposing receivers out of the end zone.