Denver Broncos rookie wide receiver Pat Bryant played just four offensive snaps in Week 1, but he logged two catches for 18 yards on three targets in Week 2. 10 different Broncos players recorded a reception in Week 2, so this could be a difficult group of pass-catchers for fantasy managers to evaluate outside of clear WR1 Courtland Sutton. A third-round pick out of Illinois, Bryant earned some preseason buzz for his performance in training camp. The 22-year-old looks like the WR4 in Denver behind Sutton, Troy Franklin, and Marvin Mims Jr. for now, and likely isn't worth rostering in redraft leagues in the immediate. However, Bryant is a name to monitor and could be worth stashing in the very deepest of league formats.

Heading into Week 2, Kansas City Chiefs wide receiver Marquise Brown was a popular waiver-wire target following his 16-target, 10-catch performance in Week 1. Even with top Chiefs wideouts Xavier Worthy (shoulder) and Rashee Rice (suspension) sidelined in Week 2, Brown was not nearly as prolific against the Philadelphia Eagles, finishing with five receptions for 30 yards. Early indications are that Worthy could return for Kansas City's Week 3 matchup against the New York Giants, which could limit Brown's target volume even further. Still, the 28-year-old looks like the Chiefs' clear WR2 until Rice is eligible to return in Week 7. Brown profiles as a WR4/low-end flex option in Week 3, although his outlook would improve if Worthy misses another game.

Tennessee Titans running back Tyjae Spears (ankle) suffered a high ankle sprain in preseason action and was placed on Injured Reserve before the start of the regular season. Given the nature of Spears' injury, he may be able to return as soon as he is eligible in Week 5 against the Arizona Cardinals. The Titans have been a one-man show at running back so far this season, with Tony Pollard having logged 38 of the team's 40 rush attempts by running backs through the team's first two games. However, this was not the case down the stretch of 2024, when Spears logged double-digit touches in each of the final three games he played. Spears finished the 2024 season with 536 yards from scrimmage and five touchdowns across 12 games and should have a consistent role in the Titans' offense once healthy in 2025. In fantasy leagues where he is available, Spears is a worthy stash in an IR spot ahead of his impending return.

San Francisco 49ers tight end George Kittle (hamstring) suffered a hamstring injury and was placed on Injured Reserve prior to Week 2. As a result, the 31-year-old will not play until at least Week 6, when San Francisco is set to take on the Tampa Bay Buccaneers. In the 49ers' first game without Kittle in Week 2, tight ends Luke Farrell and Jake Tonges combined for six catches, 45 receiving yards, and a touchdown. Kittle's return timeline could coincide with returns for 49ers quarterback Brock Purdy (toe) and wide receiver Brandon Aiyuk (knee). That could mean that San Francisco's offense could be firing on all cylinders when it welcomes Kittle back to the lineup. For fantasy managers with an open IR spot, this could be an interesting time to try and buy low on Kittle.