The Detroit Lions announced on Tuesday that they placed running back Isiah Pacheco (back) on Injured Reserve. Pacheco will now have to wait until at least Week 5 to make his Lions debut in 2026. The 27-year-old also missed time in training camp this summer with a sprained MCL in his knee, so the injury issues that plagued his final two seasons with the Kansas City Chiefs in 2024 and 2025 have followed him to Detroit. Pacheco was not expected to see much volume behind three-down workhorse Jahmyr Gibbs, but his fantasy appeal as a late-round handcuff now takes another hit. In Pacheco's absence, Sione Vaki is expected to serve as Detroit's RB2, with Jacob Saylors and Jabari Small fighting for expanded roles as well. Pacheco had a combined 1,765 rushing yards and 12 rushing touchdowns in his first two years in KC, adding 57 receptions for 374 yards and another two scores as a receiver. However, he managed to play in only 20 games over the last two seasons and produced 772 rushing yards and only two rushing TDs on 201 carries in the last two years.

Buffalo Bills wide receiver Khalil Shakir remained out of practice Tuesday, according to Joe Buscaglia of The Athletic. Shakir has not practiced since Aug. 18, when he was one of several Bills held out, and head coach Joe Brady later confirmed he was dealing with an injury. Buffalo has not disclosed what is bothering him. Shakir also missed the final two preseason games after catching two passes for 41 yards in the opener against Carolina. He led the Bills with 72 catches and 719 receiving yards in 16 games last season, adding four touchdowns. Buffalo does not open the regular season until Sept. 13 at Houston, so there is still time for Shakir to get back on the field. Still, the continued absence is worth monitoring until he resumes practice.

Tennessee Titans rookie wide receiver Carnell Tate is working through some stiffness, head coach Robert Saleh said Tuesday, according to Turron Davenport of ESPN. Saleh did not specify what is bothering Tate or indicate how much time, if any, he could miss. The fourth overall pick also sat out an Aug. 19 practice after waking up with stiffness, though it is unclear whether this is related to the same issue. Tate was back on the field two days later and finished camp on a high note, catching a team-high seven passes with two touchdowns in an Aug. 27 joint practice against Chicago. There is no indication yet how much the stiffness will affect his preparation for Week 1, making Tate's practice participation the main thing to watch over the next several days.

Chicago Bears wide receiver Luther Burden III (groin) will practice Tuesday, head coach Ben Johnson said, according to Mason Williams. Burden injured his groin during an Aug. 8 practice and missed the rest of the preseason. He returned to the field Aug. 26 but was limited to individual drills before heading inside when the Bears moved into 7-on-7 work. Tuesday's practice should give Chicago another look at where he stands as Week 1 approaches. Burden caught 47 passes for 652 yards and two touchdowns in 15 games as a rookie and is listed with the first-team offense on the Bears' current depth chart. Getting him back into team work would be another encouraging step, but his actual participation level Tuesday will matter more than the announcement itself.