San Francisco 49ers running back Christian McCaffrey (undisclosed) is in full uniform for the team's practice in Melbourne, Australia, on Tuesday, according to Nick Wagoner of ESPN. The team's final injury report for the day will tell us more about CMC's status for the Week 1 showdown on Thursday against the division-rival Los Angeles Rams, but it looks like he is heading in the right direction to be active. The Niners kept McCaffrey in bubble wrap during the preseason, and he has been sitting out of practices for several weeks due to undisclosed tightness. The star RB said the plan was always for the team to play it safe with him to have him fully ready for the start of the 2026 regular season, and it makes sense given his lengthy injury history. Until further notice, there is no reason for fantasy managers to pull CMC out of their starting lineups for Week 1. The 30-year-old four-time Pro Bowler and 2023 Offensive Player of the Year is a league-winner if he stays healthy, which is what he did in 2025, when he ran for 1,202 yards and 10 touchdowns while adding 102 receptions for 924 yards and seven touchdowns in 17 regular-season games.

Tampa Bay Buccaneers wide receiver Jalen McMillan (knee) is competing for the No. 3 role on the depth chart, and his experience in the Bucs' offense gives him an early advantage over his teammates. Chris Godwin Sr. and Emeka Egbuka (toe) project as Tampa Bay's top two wideouts, leaving McMillan and Ted Hurst III vying for the next spot in the pecking order. The good news for McMillan is that Hurst is a rookie, which means his ascension into a meaningful role might be delayed as he adapts to NFL speed. On the other hand, McMillan has been in the NFL since 2024 and has 17 games' worth of experience (plus three offseasons) under his belt. His familiarity with the system and his connection with quarterback Baker Mayfield go a long way, especially considering that McMillan averaged 10.4 fantasy points per game in PPR leagues as a rookie. Managers should expect McMillan to open the year as the Bucs' No. 3 wide receiver, which also puts him on the fantasy radar in deeper leagues. The 24-year-old is a matchup-dependent WR3/flex as it is, and he would jump into the WR3 tier on a consistent basis if Godwin or Egbuk were to miss time. As a result, McMillan should be added off the waiver wire in all 12+ team leagues.

San Francisco 49ers wide receiver De'Zhaun Stribling (shoulder) was seen wearing his full uniform for Tuesday's practice in Australia, according to Nick Wagoner of ESPN.com. It should be noted that this practice is occurring on Tuesday in Australian local time, but the timing lines up with Monday night for folks in the Pacific Time Zone of the United States. Time zone specifics aside, fantasy managers should feel encouraged that the rookie was able to don full pads with the 49ers' season opener less than three days away. Assuming he suits up for Week 1 against the Los Angeles Rams, Stribling projects to handle a decent workload alongside Mike Evans and Deebo Samuel Sr. We wouldn't recommend starting the 23-year-old in fantasy lineups until we see what his role looks like, but he's absolutely worth stashing on the bench in 12+ team leagues and even some deeper 10-team formats, too.

Dallas Cowboys running back Malik Davis is the undisputed No. 2 option on the depth chart, making him a priority target on the waiver wire in fantasy football. Specifically, he has appeal as a handcuff for managers in 14+ team leagues, as well as managers who have Javonte Williams in leagues with 10 or 12 teams. Williams is expected to occupy an every-down role this season, which means he's a candidate for some wear and tear. If he were to miss any time due to injury, his managers would want to be ready to plug and play his replacement, which would be Davis. Adding Davis off the waiver wire doesn't give managers a running back with standalone weekly fantasy value, but rather protects those managers in case Williams misses any time this season. We saw what Davis could do in the lead-back role last year, as he totaled 28 carries, 124 rushing yards, and one touchdown across the two games in which Williams played less than 50% of the snaps.