Buffalo Bills safety Jordan Poyer (hamstring) is considered week-to-week and will not play on Saturday in the Divisional Round against the hosting Denver Broncos, according to Katherine Fitzgerald of The Buffalo News. Poyer won't be available this weekend after injuring his hamstring in Sunday's Wild-Card victory over the Jacksonville Jaguars. It remains to be seen if the 34-year-old veteran will be able to return for the AFC Championship next weekend if the Bills knock off the Broncos. It's a notable loss for the Bills' defense this weekend, as Poyer has 70 tackles (31 solo), half a sack, three pass breakups, and one interception this year. Jordan Hancock will step into a starting role for Buffalo's secondary against Denver with Poyer sidelined.

The Buffalo Bills are opening the 21-day practice window for wide receiver Curtis Samuel (elbow) this week, according to head coach Sean McDermott. Samuel has been on Injured Reserve due to an elbow injury since Nov. 28, but he'll be eligible to be activated to play this Saturday in Denver against the Broncos in the AFC Divisional Round game. It's good news for the Bills after Gabe Davis (knee) tore his ACL in the Wild-Card win over the Jacksonville Jaguars on Sunday, although Samuel isn't guaranteed to play against the Broncos. Wideout Tyrell Shavers is also dealing with a knee injury and could be questionable this week. If the 29-year-old Samuel returns in the Divisional Round, he'll likely be eased back into action and won't be much of a fantasy football option. In his six games played in 2025, Samuel had seven catches for 81 yards and one touchdown.

Buffalo Bills head coach Sean McDermott said on Monday that kicker Matt Prater (quadriceps) "is in a good spot" going into the Divisional Round of the playoffs this Saturday against the Denver Broncos, according to The Buffalo News' Katherine Fitzgerald. Prater will have a similar practice schedule to last week, but he might do more this week. The 41-year-old veteran placekicker kicked field goals and extra points in Sunday's Wild-Card win over the Jacksonville Jaguars, but he was not available for kickoffs. Prater aggravated a right-quad injury in the Week 18 regular-season finale against the New York Jets, but he was able to play on Sunday against the Jags and made both his field-goal attempts (one from 50-plus yards) and all three of his extra points. Prater will have the altitude on his side in Denver this weekend, making him slightly more attractive to fantasy managers.

Buffalo Bills head coach Sean McDermott said on Monday that wide receiver Tyrell Shavers (knee) is still being evaluated after suffering a knee injury in Sunday's Wild-Card win over the Jacksonville Jaguars, according to Katherine Fitzgerald of The Buffalo News. Shavers briefly left the 27-24 win on Sunday before getting back on the field. The 26-year-old pass-catcher had just one catch on two targets for 14 yards. As of right now, Shavers should be considered questionable to play in the Divisional Round of the playoffs on Saturday against the Denver Broncos. Meanwhile, fellow wideout Gabe Davis (knee) suffered a torn ACL and will miss the rest of the year. Buffalo's receiving corps could be a little thinned out going into a tough matchup on the road against Denver. If Shavers can't play this weekend, Keon Coleman and Brandin Cooks will have elevated roles behind Khalil Shakir.