San Francisco 49ers running back Christian McCaffrey (back) was removed from the Week 18 injury report on Thursday and will play on Saturday night against the division-rival Seattle Seahawks, according to Jennifer Lee Chan of NBC Sports Bay Area. McCaffrey has dealt with a bit of back stiffness in the final month of the regular season, but it hasn't been a serious issue, and he'll be fine this weekend as the Niners look to secure the No. 1 seed, a first-round bye, and home-field advantage throughout the postseason. The 29-year-old is coming off a second straight 100-yard rushing game in the Week 17 win over the Chicago Bears on Sunday night, in which he had 23 carries for a season-high 140 yards and one touchdown on the ground. CMC added 41 receiving yards on four catches. He remains the do-it-all focal point of San Fran's offense and is a must-start, high-end RB1 in all fantasy leagues in Week 18.

San Francisco 49ers tight end George Kittle (ankle) is listed as questionable for Saturday night's game against the division-rival Seattle Seahawks in Week 18, according to Jennifer Lee Chan of NBC Sports Bay Area. Kittle missed the Week 17 win over the Chicago Bears with a mid-to-low ankle sprain, but he's feeling better and said this week that he "absolutely" plans to play on Saturday as the Niners seek the No. 1 overall seed in the NFC and a bye in the first round of the playoffs. Fantasy managers will want to check back on the 32-year-old's status on Saturday, but if he's active, as expected, he needs to be locked into all starting lineups. Kittle has found the end zone seven times in 10 games played in 20225, and in the first meeting against the Seahawks on Sept. 7, he had four catches for 25 yards and his first touchdown of the year.

San Francisco 49ers wide receiver Ricky Pearsall (knee, ankle) is listed as questionable on the final injury report for the Week 18 regular-season finale on Saturday night against the division-rival Seattle Seahawks, according to NBC Sports Bay Area's Jennifer Lee Chan. Pearsall missed yet another game in Week 16 due to knee and ankle injuries, but he returned in the Week 17 win over the Chicago Bears and looked great, securing five of his eight targets for 85 yards. The 25-year-old also played 81% of the offensive snaps. Pearsall didn't look to aggravate either of his injuries on Sunday night, so he should be on the right side of questionable to play against the Seahawks this weekend in a game that will decide the No. 1 seed in the NFC playoff picture. It's not an ideal matchup for fantasy, but if Pearsall is active, he'll be in play as a WR3/flex.

There is a possibility that the Chicago Bears will look to trade wide receiver DJ Moore this offseason, potentially to the Las Vegas Raiders in a package that would include All-Pro pass-rusher Maxx Crosby. The Raiders are heading into a full rebuild in 2026 and could use a receiver for their expected No. 1 overall pick of a quarterback. Meanwhile, the Bears need an elite pass-rusher. The 28-year-old Moore has not been a great fit in Chicago's offense in 2025 in head coach Ben Johnson's first season. After a 1,000-yard season in 2023 in his first year in the Windy City, Moore has regressed over the last two years and currently sits at 49 catches for 671 yards and six touchdowns in 16 games played. The emergence of rookie receiver Luther Burden III late this year certainly could make Moore expendable this offseason.