Washington Commanders quarterback Marcus Mariota (knee) exited during the first quarter of Sunday's Week 4 contest against the Indianapolis Colts after being sacked by two defenders on third down. The team announced that he is questionable to return. At the time of his departure, he had completed three of four pass attempts for 46 passing yards, and he also had a 35-yard rush. For the second year in a row, quarterback injuries plague the Commanders up and down the depth chart. Mariota was only playing because Jayden Daniels (elbow) was sidelined for the second week in a row after dislocating his elbow. With Mariota sidelined, Athan Kaliakmanis, a seventh-round rookie from Minnesota, has entered the game at quarterback.

Carolina Panthers wide receiver Jalen Coker (quad) is not expected to play in Sunday's Week 4 contest against the Detroit Lions, according to Adam Schefter of ESPN.com. Coker is officially listed as questionable after logging back-to-back limited practices. The 24-year-old exploded for a whopping 16 catches, 204 yards, and two touchdowns through the first two games this season, but his Week 3 performance was cut short due to the quad injury. It seemed like there was a chance he might be able to play this week, but the Panthers will ultimately hold him out. After all, there's no reason to rush him back, especially since the Panthers are on bye next week. With this week's absence and next week's bye, the Panthers are giving Coker two full weeks to recover. Tetairoa McMillan will continue to operate as Bryce Young's No. 1 target on Sunday, while Brycen Tremayne likely steps up to fill Coker's role as a sneaky WR3 option in deeper fantasy leagues.

Atlanta Falcons running back Bijan Robinson is coming off his best game of the young season, and he'll look to keep that momentum going in Week 4 against the New Orleans Saints. Robinson exploded for 213 scrimmage yards and two touchdowns in the Falcons' first win of the season on Thursday in Week 3, bringing him to a whopping 467 scrimmage yards, three touchdowns, and the overall RB3 spot through just three games. The 24-year-old is a must-start high-end RB1 in fantasy football every week regardless of matchup, and that remains the case against the Saints, who have allowed the sixth-most rushing yards, second-most touchdowns, and eighth-most fantasy points to opposing running backs in 2026. Robinson should enjoy another huge week and will push for the overall RB1 spot in total scoring once again.

Los Angeles Rams wide receiver Puka Nacua (hip) is not expected to have a limited workload as he returns from a two-game absence against the Philadelphia Eagles in Week 4, according to Adam Schefter of ESPN.com. The Rams were patient with Nacua's recovery, holding him out of back-to-back games and refusing to rush him back. Fantasy managers should be encouraged that Nacua has no limitations on Sunday. Not only does it mean that he's back to 100%, but it also indicates that he'll handle a full complement of snaps, which could help him excel offensively and rank as this week's overall WR1 in fantasy football. Presumably, Nacua will seamlessly take over for Davante Adams as quarterback Matthew Stafford's No. 1 target. In Nacua's two-game absence, Adams racked up a whopping 15 catches, 332 yards, and two touchdowns.