The Buffalo Bills are in win-now mode, and running back James Cook is one of their primary weapons on offense behind Pro Bowl quarterback Josh Allen. Cook made his third straight Pro Bowl in 2025 in his fourth year in the NFL and had a career year, leading the league in rushing yardage (1,621) with 12 rushing touchdowns on a career-high 309 carries in 17 regular-season starts. The 26-year-old led the NFL with 16 rushing touchdowns in 2024 and doesn't appear to be slowing down anytime soon. The former second-round pick in 2022 out of Georgia finished as the RB5 in half-PPR scoring in 2025, behind only Christian McCaffrey, Jonathan Taylor, Bijan Robinson, and Jahmyr Gibbs. In addition to his big numbers on the ground, Cook added 33 receptions for 291 yards and another two touchdowns through the air. Cook will go into the 2026 campaign as the clear workhorse for a Bills' offense that led the league with 159.6 rushing yards per game last year. He'll give fantasy managers a strong floor as a high-end RB1 this fall.

Former Arizona Cardinals wide receiver Greg Dortch is signing an undisclosed one-year deal with the Detroit Lions on Wednesday, sources told Tom Pelissero of the NFL Network. It's a reunion with new Lions offensive coordinator Drew Petzing, who coached Dortch the last three years in Arizona. In that time, the 27-year-old pass-catcher caught 90 of his 124 targets for 828 yards and eight touchdowns in 45 games (11 starts). The former undrafted free agent out of Wake Forest was a regular contributor in Arizona's offense, but he was never a priority option for fantasy football managers at any time. The speedy wideout will add depth to Detroit's pass-catching corps and will also be an asset on special teams, as he had 31 kick returns for 811 yards and 16 punt returns for 185 yards in 12 games in 2025. At best, Dortch will be the Lions' WR4 behind Amon-Ra St. Brown, Jameson Williams, and Isaac TeSlaa to begin next season.

The Indianapolis Colts announced on Wednesday that they signed free-agent wide receiver Nick Westbrook-Ikhine to an undisclosed deal. Westbrook-Ikhine had a career year in 2024 in his final year with the Tennessee Titans, catching 32 of his 60 passes for 497 yards and nine touchdowns in 17 games played (nine starts). The 28-year-old spent last season with the Miami Dolphins and came back down to Earth in a big way with only 11 receptions on 20 targets for 89 yards and no touchdowns in 15 games (three starts). Michael Pittman Jr. is no longer in Indy, but at best, Westbrook-Ikhine will be the team's No. 3 wideout to begin the 2026 campaign behind Alec Pierce and Josh Downs. Target-wise, he'd be fourth on the totem pole with tight end Tyler Warren also in the mix. Expect the former undrafted free agent out of Indiana to battle for the WR3 role with Ashton Dulin, Anthony Gould, and Laquon Treadwell.

Wide receiver T.Y. Hilton officially announced his retirement from professional football on Wednesday. Hilton last played for the Dallas Cowboys in 2022 after 10 seasons with the Indianapolis Colts. The 36-year-old only appeared in three games for the Cowboys and caught seven of his 10 targets for 121 yards and no touchdowns. In his prime, though, Hilton was one of the best receivers in the game, making four straight Pro Bowls from 2014 to 2017 and having four straight 1,000-yard receiving seasons from 2013 to 2016 with Indy. The former third-round pick in 2012 out of Florida International had five 1,000-yard seasons in his 11-year career and finished his successful stint in the NFL with a total of 638 receptions for 9,812 yards and 53 touchdowns on 1,086 targets. Hilton led the league in 2016 with 1,448 yards while also catching 91 passes and finding the end zone six times.