The Buffalo Bills are opening wide receiver Mecole Hardman's (calf) 21-day practice window on Wednesday, according to Maddy Glab of BuffaloBills.com. Hardman has been on Injured Reserve for the last four games after injuring his calf in the Week 11 win over the Tampa Bay Buccaneers. The 27-year-old will be eligible to play this Sunday in Week 16 against the Cleveland Browns on the road, but the Bills will have to officially activate him from IR first. When healthy, Hardman is unlikely to be a big part of Buffalo's offense, especially with Gabe Davis and Brandin Cooks now in the picture. The former Kansas City Chiefs wideout will be a top kickoff return option on special teams, though. Hardman failed to reel in his only target in his only game played for the Bills this year. He will not be on the fantasy radar for the final three weeks of the regular season.

Green Bay Packers head coach Matt LaFleur said that wide receiver Christian Watson (chest) is expected to be limited in Wednesday's practice, according to Rob Demovsky of ESPN. "He's improving. We'll just see how he's feeling out there," LaFleur said. Watson was listed as a non-participant on Tuesday's estimated injury report. He was hospitalized following a chest injury in Sunday's loss to the Denver Broncos, but doctors ruled out a long-term injury. The 26-year-old's status is up in the air for Saturday's big divisional rematch against the Chicago Bears, but it's a good sign that Watson is returning to practice. Since making his season debut halfway through the 2025 season, Watson has been Green Bay's go-to wideout, catching 28 of his 43 targets for 481 yards and five touchdowns. The former second-rounder had 89 yards and two touchdowns two weeks ago against Chicago. If he's cleared to play, Watson will have WR2 upside in the rematch in the Windy City.

Arizona Cardinals head coach Jonathan Gannon said that wide receiver Marvin Harrison Jr. (heel) will take part in the team's walkthrough practice on Wednesday, per Tyler Drake of Arizona Sports. Harrison has missed the last two games with a heel injury, but Gannon said he's doing "good." The 23-year-old former first-rounder is expected to play again this year, possibly as soon as this Sunday against the Atlanta Falcons in Week 16. Harrison has missed four of the last five games with his heel injury, and after undergoing an appendectomy. The Ohio State product has not lived up to his fourth overall draft slot through almost two full NFL seasons. When healthy in 2025, Harrison has been inconsistent with 40 catches, 594 yards, and four touchdowns in 10 games. If Harrison returns this weekend, though, he'll be on the WR2 radar in Arizona's pass-happy offense. We'll continue to keep a close eye on his status over the next two days.

Atlanta Falcons head coach Raheem Morris said that wide receiver Drake London (knee), who is considered day-to-day, will practice on Wednesday so the team can see where he's at, according to Terrin Waack of AtlantaFalcons.com. Morris said on Monday that he's "very hopeful" that London will return in Week 16 against the Arizona Cardinals. Wednesday will be the first time that the 24-year-old has practiced since spraining his left PCL back in Week 11. He's not a lock to play on Sunday against Arizona, but his return to practice at least gives his fantasy managers hope that he might be available this weekend. Tight end Kyle Pitts Sr. has had a much higher ceiling with London out, as evidenced by his monster 11-catch, 166-yard, three-touchdown spectacle last Thursday night. London is typically a must-start WR1 in fantasy when he's active, but he'll be a bit more volatile in Week 16 if he returns and is on a snap count.