Philadelphia Eagles running back Saquon Barkley (hamstring) is not at practice on Friday and has missed practice all week, according to Dave Zangaro of NBC Sports. Injuries have hit the Eagles' offense hard of late, with Barkley tweaking his hamstring in the Week 4 loss to the Los Angeles Rams and not playing in the Week 5 loss to the Jacksonville Jaguars on Sunday. Barring something unforeseen, he is trending towards missing a second straight game this Sunday against the visiting Carolina Panthers. After Will Shipley's foot injury in London last weekend, the Eagles are down to Dameon Pierce and Carson Steele in the backfield, with Tank Bigsby (abdomen) still on Injured Reserve. And if that was not enough, star quarterback Jalen Hurts (calf) is now out indefinitely with a superficial blood clot. Fantasy managers should be planning to be without Barkley for a second straight game, and when he does return, his fantasy ceiling will be lowered if Hurts remains sidelined. The next chance for Barkley to return will be in a Week 6 Monday night showdown against the division-rival Dallas Cowboys.

Washington Commanders wide receiver Stefon Diggs (hamstring) is at practice on Friday working with the rest of the receivers in individual drills, according to Zach Selby of the team's official website. Diggs injured his hamstring in the Week 4 loss to the Indianapolis Colts in London and did not play in last week's tie to the division-rival New York Giants. The 32-year-old veteran missed the first practice of the week on Thursday, but his return on Friday means that he is trending in the right direction to play on Monday night in Week 6 versus the 5-0 San Francisco 49ers. It is good news for Washington's offense, but Diggs is going to be a tough sell for starting fantasy lineups this week if he receives a questionable tag and is a game-time decision for Monday night. He has 18 catches for 170 yards and three touchdowns in his first four games for the Commanders this year. If Diggs misses a second straight game, rookie Antonio Williams would serve in the WR2 role again behind Terry McLaurin.

Washington Commanders running back Jacory Croskey-Merritt (groin) was not seen at Friday's practice, which would be the second straight practice that he has missed with a groin injury, according to Tashan Reed of The Washington Post. The 25-year-old was limited in two practices last week due to a groin injury, but he was active in the Week 5 tie to the division-rival New York Giants and handled 11 carries for 82 yards and a touchdown on the ground while not being targeted in the passing game. It is unclear if the second-year back has suffered a setback with his groin injury or if the Commanders are simply resting their RB1 going into a Week 6 tilt on Monday night against the San Francisco 49ers. The good news is that JCM has one more day to potentially return to practice on Saturday, but as of now, he is looking questionable to play in Week 6. If Croskey-Merritt cannot go on Monday night, Rachaad White would jump into the featured-back role for the Commanders, albeit in a tough matchup on the road against the 5-0 Niners.

Baltimore Ravens quarterback Lamar Jackson (ankle) is not present during the media-viewing portion of Friday's practice, which indicates that backup Tyler Huntley will likely start for the second straight week this Sunday against the division-rival Cleveland Browns, according to Jamison Hensley of ESPN. Jackson missed every practice this week and has not suited up since spraining his left ankle in the Week 4 win over the Tennessee Titans. Huntley has won his last three starts as a fill-in starter for Jackson, so they definitely are not going to rush Jackson back if he is not quite ready. In the three victories with Huntley under center, the Ravens have averaged 33.7 points. Huntley has become one of the better backups in the league, and he will once again be on the QB2 streaming radar in superflex fantasy leagues if he makes his second straight start. Fantasy managers should be ready to be without Jackson for a second straight week. If he is ruled out on Friday, his next chance to play will be at home for another divisional contest on Sunday, Oct. 25, against the Cincinnati Bengals.