San Francisco 49ers tight end George Kittle's production took a big step back in Week 5, when he caught five of his six targets for a mere 24 receiving yards. It was a disappointment after a three-week stretch where he averaged 77.3 receiving yards and scored at least one touchdown in each game. Kittle could be in for a major rebound in Week 6. For starters, the 49ers will face the Washington Commanders, who have rank in the bottom five in fantasy points, receptions, receiving yards, and touchdowns allowed to opposing tight ends. Secondly, given the spate of injuries in San Francisco's wide receiver room, Kittle is in line to see more time as Brock Purdy's first read. As usual, Kittle is among the top options at tight end this week and should is a lock for fantasy lineups.

San Francisco 49ers kicker Eddy Pineiro missed a field goal attempt from 52 yards out but was good on his 44-yard try that ended up being the difference in last week's 32-39 win over the Seahawks. He was 3-for-3 on extra point attempts, as well. The 49ers' efficiency on offense has eaten into Pineiro's production in 2026, allowing him just eight field goal attempts (with five makes) through the first five weeks. Pineiro could see more action this week, though. The 49ers' upcoming meeting with the Commanders has one of the highest point totals on the Week 6 slate. If the offensive bonanza comes to fruition, it will put Pineiro in a good spot for some extra chances to put points on the board. Pineiro has a top-12 projection in Week 6, and fantasy managers can feel good about including him in starting lineups.

San Francisco 49ers wide receiver Brandin Cooks had one catch in his team debut last week, but it was good for a seven-yard touchdown. Amid injuries to Deebo Samuel Sr. (hamstring) and Mike Evans (ribs, Achilles), Cooks was mostly rotated into two-WR sets, and his snap share was nearly equal to that of Samuel, Jacob Cowing (ankle), and Jordan Watkins. With Samuel ruled out for Week 6, and Evans questionable after not practicing all week, Cooks might take another step forward on Monday night. The 49ers will host the Commanders in the final game of the slate, and Washington has allowed the fourth-most fantasy points to opposing wide receivers in 2026. Cooks currently projects as a WR5 in Week 6. He is best suited for deep leagues and is worth stashing elsewhere as a late pivot option for teams rostering Evans.

San Francisco 49ers wide receiver Mike Evans fought through a rib injury to snag seven receptions for 117 yards and a touchdown on 10 targets in Week 5. Evans logged three straight DNPs ahead of the 49ers' Week 6 matchup with the Washington Commanders, though he was able to work out on the side. Not only was Evans still bothered by the rib ailment, but he is also battling Achilles soreness. If Evans can tough out the injuries again, he could have another big week. The Washington Commanders have given up the fourth most fantasy points to wide receivers in 2026, and have given up at least 120 yards and a touchdown to a wide receiver in three of their first five games. Evans projects as a WR2, but if a late decision comes for Evans to sit, fantasy managers have a grab bag of receivers to pivot to on Monday night that includes Jacob Cowing (ankle), Brandin Cooks, and Jordan Watkins.