Arizona Cardinals quarterback Jacoby Brissett may be down one of his receivers going forward, but he still ranks as a mid-range QB2 with significant QB1 upside. Brissett has the 12th-most fantasy points among quarterbacks this season, and he's coming off a strong fantasy performance against the Lions in which he threw for 292 yards, three touchdowns, and one interception. There's a bit of concern that Brissett's value could dip slightly after the Cardinals traded away Marvin Harrison Jr., but the impact of that move is relatively minor. Brissett still has Trey McBride and Michael Wilson at his disposal, giving him two highly talented weapons who will keep this Arizona passing offense playing at a high level going forward. Brissett could benefit from another negative game script against the Rams in Week 6, although it won't come easy against a defense anchored by veteran lineman Aaron Donald.

Los Angeles Rams wide receiver Davante Adams caught five of his seven targets for 51 yards and two touchdowns during Monday's Week 5 loss against the Buffalo Bills in overtime. Adams' first touchdown tied the game in the second quarter, and his next touchdown pulled the Rams within one point before an extra point tied it up. The 33-year-old has now scored 20+ fantasy points in three of his last four games, although two of those contests were somewhat skewed by the absence of Puka Nacua. With that being said, Nacua and Adams have shown that they can coexist as fantasy-relevant options, with the former ranking as a high-end WR1 and the latter checking in as a mid-range WR2. Adams, who has 18 touchdowns over his last 18 games, will look to remain an elite scoring threat in Week 6 against the Arizona Cardinals, who most recently allowed Jameson Williams to find the end zone twice.

Los Angeles Rams quarterback Matthew Stafford completed 40 of his 54 pass attempts for 383 passing yards, three passing touchdowns, and zero interceptions during Monday's Week 5 loss against the Buffalo Bills in overtime. He also took one sack along the way. Stafford put up a valiant effort against the Bills, setting a new career-high for completions in a single game. A late touchdown pass forced overtime, and Stafford got the Rams in position to win the game with an overtime field goal, but the kick was no good. Stafford now has nine touchdowns over his last four games, and Monday also represented his first game this season without an interception. Even though the 38-year-old doesn't have any rushing upside, he's still a flashy QB1 in fantasy football because of his passing prowess.

Buffalo Bills running back James Cook III logged 25 carries, 111 rushing yards, and two rushing touchdowns during Monday's Week 5 win over the Los Angeles Rams in overtime. He also converted his lone target into a seven-yard reception. Although Cook scored twice and handled an enormous workload against the Rams, he also dealt with some serious ball security issues. The 27-year-old finished with two fumbles (one fumble lost), nearly costing the Bills the game. This is nothing new for Cook, who has 10 fumbles over his last 22 games. On a more positive note, he has five touchdowns over his last four games and remains a high-end RB1 option in fantasy football. He continues to trend upward ahead of Week 6 against the Las Vegas Raiders, who just surrendered a whopping 45 points to the Patriots.