The Athletic's Vic Tafur reports San Francisco running back Christian McCaffrey (undisclosed) did not participate in Saturday's practice. The star running back has been held out of practices and preseason action due to undisclosed "tightness." However, head coach Kyle Shanahan said earlier in the week that if it were the regular season, McCaffrey would be practicing and playing. With his injury history, the team has understandably opted to be cautious. In the two seasons following a 330-plus-touch season, he has played a combined seven games (three games in 2020 and four games in 2024). McCaffrey saw over 400 touches last season that produced 2,126 total scrimmage yards and 17 total touchdowns. The 30-year-old will be a high-risk, high-reward fantasy option for managers heading into drafts in 2026.

NBC Sports Bay Area & California's Matt Maiocco reports San Francisco 49ers rookie wideout De'Zhaun Stribling (shoulder) is considered day-to-day with a shoulder injury. Stribling reportedly sustained his shoulder injury during Thursday's 41-17 preseason win against the Los Angeles Chargers. The 23-year-old had four catches for 46 yards on five targets in his second preseason outing. Stribling has become a trendy late-round target for fantasy managers after teammate Ricky Pearsall (knee) underwent season-ending knee surgery in early August and Mike Evans has missed time due to a quadriceps strain. Since then, Stribling has turned heads in training camp and produced strong outings in preseason action. However, he has not been able to fully maximize his opportunity to carve out a role in the 49ers' offense since this is the second injury he has had in August. Stribling should still be viewed as a later-round target in fantasy football drafts with high upside.

ESPN's Marc Raimondi reports Atlanta Falcons quarterback Michael Penix Jr. has been cleared for 11-on-11 drills. Head coach Kevin Stefanski said that Penix will practice with the team on Monday. Penix has been recovering from a torn ACL in his left knee that he sustained in Week 11 against the Carolina Panthers last season. This marked Penix's third knee surgery in his career after having two ACL reconstruction surgeries on his right knee in college. The 26-year-old was the QB26 through Week 11 while averaging 13.7 points per game. After struggling in his sophomore season, the Falcons chose to bring in veteran quarterback Tua Tagovailoa to compete for the starting quarterback role. Tagovailoa currently has the upper hand in the competition since Penix has not been cleared to participate in full team drills until now. However, Tagovailoa has had shaky performances in joint practices with the Indianapolis Colts and in his preseason debut against the Denver Broncos that could allow Penix to jump back into the race.

The Coachspeak Index reported that Houston Texans head coach DeMeco Ryans thinks running back Woody Marks will have a special season in 2026. "I'm seeing a more dynamic, faster, more physical runner," Ryans said. "He's running behind his pads...He just looks faster, looks more decisive. He's looking really special, looking like he's gonna have a special year." Marks was an inconsistent, high-upside waiver-wire pickup in fantasy football as a rookie last season. The 25-year-old surpassed 12 PPR points five times while failing to reach eight fantasy points six times after Week 4. There was interest in Marks in the fantasy community this season until David Montgomery arrived in Houston. However, Marks has reportedly had a strong training camp and consistently received praise from coaches. He is currently RotoBaller's RB46 in PPR formats, and it will be intriguing to see how the team deploys him this season.