Houston Rockets guard Reed Sheppard (knee) is questionable for Friday's matchup with San Antonio due to a left knee contusion and bone bruise, per the Houston Chronicle's Varun Shankar. The 22-year-old is coming off a quiet opener against Dallas, scoring three points on 1-for-6 shooting from deep with three turnovers in 16 minutes. Marcus Smart played 26 minutes off the bench, while Fred VanVleet's return has tightened Houston's backcourt rotation. If Sheppard sits, Smart and Bogdan Bogdanovic could see additional work. Sheppard averaged 13.5 points, 2.8 threes and 1.5 steals last season.

Houston Rockets center Steven Adams (calf) is questionable for Friday's matchup with San Antonio in Austin, per the Houston Chronicle's Varun Shankar. The 33-year-old missed Wednesday's opener after developing right calf tightness following a practice earlier in the week. Houston also plans to sit Adams for one leg of back-to-backs early in the season, with another game Saturday in Atlanta. He averaged 8.6 rebounds in 22.8 minutes last season. If Adams remains out, Clint Capela should continue backing up Alperen Sengun, though Capela logged only eight minutes in the opener.

San Antonio Spurs guard De'Aaron Fox (wrist) is questionable for Friday's matchup with Houston due to a right wrist sprain. The two-time All-Star played 32 minutes in Tuesday's season opener, finishing with 14 points, seven rebounds, seven assists, and one steal on 6-for-9 shooting. San Antonio visits Dallas on Saturday to complete a back-to-back, giving the Spurs another reason to be cautious with Fox. If he sits Friday, Dylan Harper and Stephon Castle should take on more playmaking responsibility, while Julian Champagnie could move into the starting five.

San Antonio Spurs forward Keldon Johnson (mouth) is questionable for Friday's game against Houston in Austin, per Matt Guzman. The reigning Sixth Man of the Year needed three stitches for a deep cut inside his right cheek after Tuesday's 116-104 loss to Oklahoma City but still finished with 10 points, four rebounds, one assist, and two steals in 20 minutes. With Tobias Harris (calf) also out, Julian Champagnie could take on a larger wing role if Johnson sits, while Harrison Barnes and Carter Bryant may also pick up minutes.