Kansas City Royals right-handed reliever Carlos Estevez (shoulder, foot) left his minor-league rehab outing on Wednesday early at Triple-A Omaha with right-shoulder discomfort, according to Anne Rogers of MLB.com. Estevez recorded two outs, but his velocity was down, and he exited after the second out when a trainer came to visit with him. Estevez has been on the 15-day injured list since he was hit by a comebacker on his left foot after his first appearance of the season. The 33-year-old Dominican veteran and two-time All-Star allowed six earned runs in one-third of an inning of work before being hit in the foot, and his velocity was noticeably down in spring training as well. Estevez might have recovered from his foot injury, but now he has shoulder concerns and could need to restart a rehab assignment. It's becoming harder to justify stashing Estevez in fantasy leagues, and Lucas Erceg's run as KC's primary closer could be extended, depending on how serious Estevez's shoulder injury is. Estevez is currently rostered in 64% of Yahoo leagues.

Houston Astros right-hander Lance McCullers Jr. (finger) was pulled from his start early on Wednesday against the visiting Los Angeles Dodgers in the third inning, and The Athletic's Chandler Rome reported that McCullers was looking down at his finger before manager Joe Espada and a trainer came out to check on him. McCullers has dealt with blister issues in the past, as well as several arm injuries that derailed his career for quite some time. It was a rough outing for the 32-year-old veteran before being pulled, as he allowed six earned runs on four hits (one homer) while walking three and striking out four in just 2 2/3 innings against the first-place Dodgers to pick up his third loss of the year. The poor outing raised McCullers' ERA to 7.41 in seven starts this year. The former first-rounder in 2012 will be droppable in most leagues if he finds his way to the injured list. McCullers is only rostered in 10% of Yahoo leagues right now.

Cincinnati Reds right-handed closer Emilio Pagan (hamstring) said he suffered a Grade 2 hamstring strain on Tuesday night, according to Gordon Wittenmyer of The Cincinnati Enquirer. Doctors told Pagan that it will be four to eight weeks before he can return to the mound for the Reds, but it's a best-case scenario after the level of pain that he experienced on Tuesday night when he was carted off the field against the Chicago Cubs. "Leaving the field yesterday, I thought my season was done," Pagan said. The Reds placed Pagan on the 15-day injured list on Wednesday. The 34-year-old veteran reliever will be dropped in a lot of fantasy leagues after this news. It's not like he was pitching well before his hamstring issues, sporting a 6.43 ERA, 1.43 WHIP, six saves, 11 strikeouts, and six walks in 14 innings pitched out of the bullpen. Going forward, right-hander Tony Santillan is the name to know for a waiver-wire pickup for save opportunities, although righty Graham Ashcraft could also see some save chances with Pagan sidelined.

Minnesota Twins right-hander Joe Ryan (elbow) is officially listed as the team's scheduled starter for Saturday's game in Cleveland against the division-rival Guardians, according to Aaron Gleeman of The Athletic. The Twins pulled Ryan from his last outing against the Toronto Blue Jays on Sunday after just nine pitches with soreness in his right elbow. Thankfully, an MRI exam ruled out any structural damage for the 29-year-old, and he's been cleared to make his next start this weekend in a plus matchup against a Guardians team that ranks 22nd in OPS (.693). Despite the plus matchup, Ryan will be extra risky for fantasy managers and could be on a shorter leash on Saturday after throwing only nine pitches his last time out. The former seventh-round pick by the Tampa Bay Rays in 2018 out of Cal State Stanislaus has gone 2-3 this year for the Twins with a 3.72 ERA (3.01 FIP), 1.06 WHIP, and 40:10 K:BB in 38 2/3 innings across his eight starts.