Miami Marlins middle infielder Xavier Edwards (thumb) is out of the starting lineup on Friday against the San Francisco Giants because he has been dealing with soreness in his thumb, according to Kevin Barral of Fish on First. Edwards is day-to-day and is expected to return to the lineup for Game 2 of the series against the Giants on Saturday. With Edwards out at LoanDepot Park on Friday, Javier Sanoja will start at the keystone for the Fish and bat ninth against Giants right-hander Landen Roupp. This will be the second straight game that Edwards has started on the bench after also sitting out on Wednesday. The 26-year-old switch-hitter and former first-rounder in 2018 by the San Diego Padres is hitting a strong .291/.375/.425 with an .801 OPS, six homers, 26 RBI, 11 stolen bases, and 43 runs scored in 275 at-bats this year, but his thumb injury could help explain why he's gone just 10-for-52 (.192) with six RBI, two runs, three steals, eight walks, and 13 K's in 15 games so far in June. Despite the recent cold spell and injury, fantasy managers should be looking to get Edwards back in their starting lineups if he returns on Saturday.

Toronto Blue Jays first baseman Vladimir Guerrero Jr. (back) left Friday's game early at Wrigley Field against the Chicago Cubs after appearing to tweak his back in the sixth inning, according to Sportsnet. Before departing early, Guerrero went 0-for-3 at the plate to lower his season average to .276 with a .731 OPS. He was replaced at first base by Charles McAdoo. We don't have an update on the severity of Vladdy's back/side injury just yet, but knowing that a back injury recently caused him to miss some time, this is absolutely an injury that could land the All-Star slugger on the injured list. The 27-year-old Canadian entered Friday's game in Chicago with a strong .279 batting average (72-for-258) and .367 on-base percentage in 71 games in 2026, but he's only homered four times in 303 plate appearances. His underlying metrics don't exactly give fantasy managers a ton of confidence that more power is coming, as he ranks in the 53rd percentile in expected slugging, the 23rd percentile in xISO, and the 64th percentile in hard-hit rate. Stay tuned for an update on his back injury.

Kansas City Royals infielder/outfielder Maikel Garcia (hand) is out of the team's starting lineup again on Friday against the visiting St. Louis Cardinals, per MLB.com. Garcia's injury (just soreness) to his right hand doesn't seem serious, but this is the third straight game that he will be missing after he left early on Tuesday against the Washington Nationals. For now, he's being considered day-to-day with something that he has battled over the last month. If he cannot return to action at some point this weekend (the Royals have an off day on Sunday), it wouldn't be a surprise to see him land on the injured list next week. Nick Loftin is starting at third base again on Friday and is batting sixth versus Cardinals right-hander Michael McGreevy. The 26-year-old Garcia is primarily valuable in all fantasy leagues for his speed and multi-position eligibility (second base, third base, shortstop, and the outfield). He enters Friday's action with a .266/.326/.378 slash line, .705 OPS, only three home runs, 30 RBI, 32 runs scored, and five stolen bases in his 259 at-bats.

Kansas City Royals shortstop Bobby Witt Jr. (knee) will sit out of Friday's contest against the visiting St. Louis Cardinals after injuring his knee on Thursday, according to MLB.com. Tyler Tolbert will make the start at shortstop for the Royals and will bat ninth against Cardinals right-hander Michael McGreevy. The Royals have a scheduled day off on Saturday, so Sunday will be the next time that Witt will have a chance to return. Fantasy managers will want to check back then to see if the star shortstop is available to return. The 26-year-old two-time All-Star and two-time Silver Slugger winner continues to contribute across all categories for fantasy managers in 2026, slashing .294/.368/.465 with an .833 OPS, 10 home runs, 32 RBI, a league-high 28 stolen bases, and 40 runs scored in a league-high 76 games played and 337 plate appearances. Whenever Witt returns to KC's lineup, he'll be a must-start in fantasy. Taylor should be ignored in all DFS formats against McGreevy.