Kansas City Royals third baseman Maikel Garcia (hamstring) is sitting out for a sixth straight game on Friday in Minnesota against the division-rival Twins, according to MLB.com. Nick Loftin will make another start at the hot corner for the Royals and will hit eighth against Twins right-hander Zebby Matthews. Garcia entered Thursday's series opener against the Twins as a pinch-hitter, though, so it would not be a surprise to see him return to action for the third game of the series at Target Field on Saturday. After being named an All-Star for the first time in his career in 2025, the 26-year-old Venezuelan third baseman has underwhelmed in 2026, hitting .268 (60-for-224) with three home runs, 21 RBI, 28 runs scored, and four stolen bases across 57 games and 247 plate appearances. He was beginning to heat up before his hamstring injury, though, going 11-for-32 (.344) with two doubles, three RBI, and two runs scored in nine games since May 22.

After their gut-wrenching 7-6 loss to the Chicago Cubs at Wrigley Field on Thursday night after they blew a three-run lead in the ninth inning, the Athletics designated right-handed reliever Joel Kuhnel for assignment, according to Bob Nightengale of USA Today Sports. Kuhnel, who had been part of the team's closer-by-committee approach this year, picked up a hold but was hit with the loss on Thursday night by allowing four earned runs on five hits in just two-thirds of an inning. The 31-year-old former 11th-round pick by the Cincinnati Reds in 2016 out of the University of Texas at Arlington allowed seven earned runs on 10 hits (one homer) while walking one and striking out just one in 4 2/3 innings in his last four appearances out of the bullpen to inflate his season ERA to 4.21 (3.96 FIP). With Kuhnel now out of the picture for the A's bullpen, left-hander Hogan Harris could be the current favorite for saves in Sacramento.

St. Louis Cardinals rookie second baseman JJ Wetherholt (lower body) is still dealing with some lower-body soreness and remains out of the team's starting lineup for Friday's series opener at Busch Stadium against the division-rival Cincinnati Reds, according to MLB.com. Bryan Torres is starting at the keystone for St. Louis and will hit fifth in the batting order against Reds right-hander Brady Singer. Wetherholt was held out of the lineup on Wednesday and will start on the bench again on Friday despite the team having a scheduled day off on Thursday. He's considered day-to-day for now. Fantasy managers will need to check back on Saturday to see if he's back in the lineup for Game 2 of the series. Wetherholt, a former seventh overall pick in 2024 out of West Virginia University, has held his own in his first year in the big leagues as a full-time player, hitting .249/.357/.400 with a .757 OPS, nine homers, 25 RBI, seven steals, and 40 runs scored in 58 games and 266 plate appearances. In 10 games since May 23, Wetherholt is hitting .293 (12-for-41) with two doubles, an RBI, five runs, and a stolen base.

Athletics outfielder Brent Rooker (knee) is serving as the designated hitter and is batting cleanup for the A's in Friday's series opener at Daikin Park against the hosting Houston Astros and right-hander Peter Lambert, per MLB.com. Rooker has been bothered by some knee soreness of late, which is why the A's gave him the day off on Thursday in the final game of the series at Wrigley Field against the Chicago Cubs. The team probably also wanted to give the right-handed slugger a day of mental rest after a really rough start to his 2026 campaign. The 31-year-old veteran outfielder enters Friday's action with a .195/.276/.360 slash line, .635 OPS, eight home runs, 26 RBI, 16 runs scored, and two steals in his 164 at-bats. Rooker has gone 5-for-37 with a homer, two RBI, four runs scored, two walks, and 13 strikeouts in his last 10 games. Fantasy managers are looking for any signs of life from Rooker at this point, but it might be wise to keep him benched until that happens. He's gone hitless in just one career at-bat against Lambert.