The Houston Astros announced that right-hander Lance McCullers Jr. (undisclosed) has been scratched from his scheduled start on Tuesday in Minnesota against the Twins for undisclosed reasons. Right-hander Jason Alexander will start in his place. Fantasy managers will want to check back later for a reason why McCullers won't make his start at Target Field. The 32-year-old veteran and former first-rounder in 2012 hasn't really been consistent enough to be rostered in mixed fantasy leagues, as he entered the day with a 2-3 record, 6.86 ERA (5.06 FIP), and 1.52 WHIP with 43 strikeouts and 22 walks in 39 1/3 innings pitched across his eight starts in 2026. The oft-injured hurler did bounce back in his last outing on May 13 against the Seattle Mariners, allowing two earned runs while walking two and striking out six in 5 1/3 innings of work, but he's only had quality starts in two of his eight appearances so far this year. McCuller is currently rostered in under 10% of Yahoo leagues.

Toronto Blue Jays infielder Ernie Clement (illness) is out of the starting lineup on Tuesday against the division-rival New York Yankees due to strep throat, according to Hazel Mae of Sportsnet. Clement told Mae that "it started yesterday." Davis Schneider is starting at second base for Toronto and will hit seventh for the Jays against Yankees right-hander Will Warren in the Bronx. Schneider has faced Warren only two times in his career, but has a home run and two RBI. The 30-year-old Clement should be considered day-to-day for now. The former fourth-round selection by the Cleveland Guardians in 2017 out of Virginia hasn't provided fantasy managers with much besides a decent average (.281) in 2026. He also has a .309 on-base percentage, .406 slugging percentage, .714 OPS, three home runs, 16 RBI, 18 runs scored, and a steal in 188 plate appearances across his 46 games played. Clement is also useful in deeper fantasy leagues with eligibility at first, second, third, and shortstop. He's rostered in just over half of Yahoo leagues.

Baltimore Orioles second baseman Jackson Holliday (hand) was reinstated from the 10-day injured list on Monday before the series opener against the division-rival Tampa Bay Rays, but he didn't play. Holliday will start at second base and bat seventh in the lineup in his 2026 season debut against Rays right-hander Griffin Jax. The 22-year-old former first overall pick in 2022 needed surgery for a fractured hamate bone in his right hand in February, but he's just now making his season debut due to multiple setbacks he encountered while on his minor-league rehab assignment. Fantasy managers still holding Holliday have to be disappointed that he's hitting near the bottom of the batting order, but there is plenty of time to move his way up the lineup if he produces offensively. Don't be surprised if Holliday is slow to get back into a rhythm at the plate after slashing just .176/.291/.284 during his rehab assignment. Holliday is an emerging power/speed threat who is in just his second full season in the majors. He's currently rostered in 41% of Yahoo leagues, but he'll become a priority waiver addition if he starts putting up numbers in Baltimore.

Boston Red Sox outfielder Ceddanne Rafaela (hamstring) is back in center field and will bat out of the two-hole for Tuesday's game against the hosting Kansas City Royals and left-hander Bailey Falter, according to MLB.com. Rafaela was not in the starting nine for Monday's series opener against the Royals, but he entered as a defensive replacement, and now he's back in the starting lineup for Game 2 at Kauffman Stadium. Not only is the 25-year-old native of Cuacao one of the best defensive center fielders in the game, but he's also been one of Boston's best producers on offense, entering Tuesday's tilt with a .284/.354/.432 slash line with a .786 OPS, four home runs, 19 RBI, 18 runs scored, and three stolen bases across 45 games and 164 plate appearances. Rafaela has been even better in May, going 17-for-53 (.321) with three of his home runs, two doubles, nine RBI, three steals, and five runs scored in 16 games played. Get him back into your starting lineups in all traditional formats on Tuesday.