Milwaukee Brewers first baseman Andrew Vaughn (hand) is battling a hand injury, per Adam McCalvy of MLB.com. McCalvy reports that Vaughn's injury is prompting Milwaukee to promote catching prospect Jefferson Quero to provide the team the flexibility to use normal backup catcher Gary Sanchez at first base. Vaughn appears likely to be placed on the injured list, but it's not entirely clear how much time Milwaukee expects him to miss. The 27-year-old started Milwaukee's opener on Thursday against the Chicago White Sox at first base and batted cleanup. Vaughn closed the 2025 season on a tear, hitting .308/.375/.493 with nine home runs, 46 RBI, and 26 runs scored across 254 plate appearances with Milwaukee. If he's forced to miss time, Sanchez and left-handed hitting outfielder/first baseman Jake Bauers could be the leading candidates to cover first base for the Brewers.

Los Angeles Dodgers closer Edwin Diaz converted his first save chance with his new team on Friday night in the Dodgers' 5-4 win over the Arizona Diamondbacks. Diaz allowed a walk but struck out two without allowing a hit in a scoreless ninth inning. The 32-year-old signed a three-year, $69 million contract with Los Angeles this past winter after a six-season run with the New York Mets. Across 66 1/3 innings with New York in 2025, Diaz recorded a 1.63 ERA and a 0.87 WHIP with 98 strikeouts, six wins, and 28 saves. He's recorded a strikeout rate of at least 38% in six out of the last seven seasons where he's pitched. When healthy, Diaz is arguably the best closer in baseball and should get plenty of save chances while pitching for the Dodgers in 2026.

Pittsburgh Pirates outfielder Oneil Cruz is not in the starting lineup for his team's matchup with the New York Mets and left-handed starting pitcher David Peterson on Saturday. Switch-hitter Jake Mangum will take Cruz's spot in center field and bat ninth. Cruz's 2026 season got off to a rough start in Pittsburgh's opener against the Mets on Thursday, as he struck out three times in five plate appearances and misplayed a ball in center field that led to multiple runs for New York. The 27-year-old owns a slash line of .172/.247/.313 with a 38.4% strikeout rate in 401 career plate appearances against left-handed pitching. It appears that Pittsburgh is planning to deploy Cruz in a true big-side platoon role in center field, at least to begin 2026. Cruz's power/speed profile makes him a high-upside fantasy outfielder, but his ability to rack up counting stats is limited by his lack of everyday playing time.

Toronto Blue Jays third baseman Kazuma Okamoto has been moved up to the cleanup spot in his team's lineup for Toronto's matchup on Saturday against the Athletics and left-handed starting pitcher Jeffrey Springs. Okamoto batted seventh for the Blue Jays' opener on Friday with the A's throwing right-handed starting pitcher Luis Severino. Okamoto performed well in his MLB debut, going two-for-three with a walk and two runs scored. The 29-year-old is expected to play a key role as the Blue Jays' everyday third baseman in 2026 after the team brought him over from Japan on a four-year, $60 million contract. Okamoto's prominent spot in the lineup against left-handers should help him rack up counting stats for fantasy managers, and could be an indicator of his potential to move up in the lineup against righties if he proves he can handle MLB pitching.